A Complete Guide to Staying Safe When Illness Strikes
Living with diabetes means every aspect of health requires careful management, and that becomes especially critical when you fall ill. Whether you are dealing with a cold, flu, stomach bug, or infection, sickness can dramatically affect blood glucose levels and increase the risk of serious complications.
When you are unwell, your body releases stress hormones such as cortisol, adrenaline, and glucagon. These hormones are part of the natural immune response, but they also trigger the liver to release stored glucose into the bloodstream while simultaneously reducing insulin sensitivity.
The result is often a sharp and sustained rise in blood glucose levels, even if you are eating less than usual.
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Stress Hormones
These symptoms can complicate matters further by causing dehydration and, in some cases, hypoglycaemia—particularly if you are on insulin or sulphonylureas and cannot keep food down.
Follow these critical guidelines to stay safe when illness strikes
This is the single most important rule. Even if you are not eating, your body still needs insulin or oral diabetes medications. Stopping medication is one of the most common causes of DKA.
Check your blood sugar at least every 2-4 hours when unwell. If you use a CGM, keep a close eye on trends and alerts. Illness causes rapid and unpredictable swings.
If blood glucose rises above 13 mmol/L (~240 mg/dL), test for ketones. Blood ketone levels above 1.5 mmol/L require immediate action.
Aim to drink at least 200ml of fluid per hour. Choose sugar-free fluids when blood sugar is high, and sugary drinks when low or unable to eat.
Replace meals with easily digestible carbohydrates like toast, crackers, rice, soup, yoghurt, or porridge. Small regular portions prevent hypoglycaemia.
If unsure about dose adjustments, contact your diabetes team rather than guessing. They can provide personalised guidance for your situation.
2-4h
Check Interval
Illness can cause rapid and unpredictable swings in blood glucose levels, so more frequent monitoring helps you catch dangerous changes early and respond appropriately.
| Situation | Frequency |
|---|---|
| During illness | Every 2-4 hours |
| Using CGM | Continuous monitoring |
| When BG > 13 mmol/L | Every 1-2 hours + ketones |
Ketone testing is particularly important for people with Type 1 diabetes, but anyone on insulin should be prepared to test during illness.
Dehydration worsens hyperglycaemia and accelerates the progression towards DKA or HHS. Aim to drink at least 200ml per hour.
When BG is HIGH
Water, sugar-free squash, clear broth
When BG is LOW or can't eat
Flat lemonade, fruit juice, full-sugar squash
If you cannot manage your usual meals, replace them with easily digestible carbohydrate-containing foods. Small amounts regularly are better than large meals.
Certain diabetes medications carry additional risks during illness. Understanding these risks helps you take appropriate precautions.
Should be temporarily paused during vomiting, diarrhoea, or dehydration because of the risk of lactic acidosis.
(e.g., dapagliflozin, empagliflozin) Should be stopped during acute illness as they increase risk of euglycaemic DKA.
You may need to increase doses during illness. Contact your diabetes team for personalised sick day action plans.
Risk of hypoglycaemia may increase if food intake is reduced. Monitor closely and have fast-acting glucose available.
Tip: Ask your diabetes team for a personalised sick day action plan before you need it.
Do not wait to see if things improve on their own. DKA and HHS can progress rapidly, and early intervention dramatically improves outcomes.
Blood ketone levels above 3.0 mmol/L
This constitutes a medical emergency
Persistent vomiting
Unable to keep fluids or medication down for more than 2 hours
Blood glucose remains above 20 mmol/L (360 mg/dL)
Despite taking correction doses
Signs of DKA
Deep rapid breathing, fruity-smelling breath, or abdominal pain
Confusion, drowsiness, or loss of consciousness
Any altered mental state requires immediate action
DKA
Diabetic Ketoacidosis
More common in Type 1
HHS
Hyperosmolar State
More common in Type 2
NHS 111 is available 24/7 for urgent medical help when you're not sure what to do.
Preparation is key. Every person with diabetes should have a sick day kit ready before illness strikes.
Blood Glucose Meter
With spare strips and batteries
Blood Ketone Meter
With spare ketone strips
Thermometer
To monitor fever
Fluids
Sugar-free and sugary drinks
Easy-to-Eat Snacks
Toast, crackers, yoghurt
Sick Day Action Plan
Written guidance from your diabetes team
Emergency Contacts
GP, diabetes nurse, NHS 111
7
Essential Items
Effective diabetes management extends well beyond sick day protocols. Long-term resilience depends on consistent self-care.
Quality Sleep
Stress Management
Regular Activity
Proper Nutrition
When the body is well supported on an everyday basis, it is better equipped to handle the additional metabolic stress that illness brings.
Maintaining overall cognitive function and physical resilience is important for anyone managing a chronic condition like diabetes. Many people find that supporting brain health helps them stay alert and make better self-management decisions.
If you are curious about evidence-based approaches to cognitive support, our introduction to nootropics provides a comprehensive starting point.
Print this checklist and keep it with your sick day kit for quick reference
Ketones above 3.0 mmol/L
Medical emergency - call 999
Vomiting persists
Can't keep fluids/medication down for 2+ hours
BG remains above 20 mmol/L
Despite correction doses
Signs of DKA
Deep breathing, fruity breath, abdominal pain
Confusion or unconsciousness
Any altered mental state
NHS 111 (24/7)
For urgent medical help when you're not sure what to do
A visual summary of the key actions to take when you're unwell with diabetes
What to do when illness strikes
Your body still needs insulin or oral meds even if you're not eating
More often if levels are fluctuating rapidly
If BG rises above 13 mmol/L (240 mg/dL)
At least 200ml per hour
Toast, crackers, rice, soup, yoghurt
If unsure about medications or doses
Ketones >3.0
Persistent Vomit
BG >20 mmol/L
DKA Signs
Confusion
Call NHS 111 or 999 Immediately
Always consult your healthcare team for personalised diabetes management advice
This article is for informational purposes only and does not constitute medical advice. Always consult your GP, diabetes specialist nurse, or endocrinologist for personalised guidance on managing diabetes during illness. The information provided is based on general guidelines and may not apply to your specific situation.
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